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Pharmacokinetic and pharmacodynamic properties of hepatitis C agents

Two clinical trials are on-going in Vietnam and Myanmar, investigating the efficacy and safety of sofosbuvir and daclatasvir in the treatment of Hepatitis C. Bioanalytical assays will be developed to quantify these drugs in biological fluids, such as plasma and whole blood. Pharmacokinetic and pharmacodynamic samples will be collected in these studies so that the pharmacokinetic properties can be evaluated, and linked to their pharmacodynamic effect (viral elimination).