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Pharmacokinetic and pharmacodynamic properties of anti-infective agents

A collaboration between MORU and DNDi is ongoing to provide pharmacokinetic and pharmacodynamic modelling support to inform the development of novel drugs for neglected tropical diseases (e.g. leishmaniasis, Chagas disease and filariasis). The initial focus will be on filariasis with the aim to provide a rational modelling framework for in-vitro to in-vivo scaling, animal to human scaling, healthy volunteer to patient scaling, and to perform phase I-IV clinical trial evaluation of novel drugs under development.