Future vision Malaria & Critical illness
Following the large multi-centre multi-country TRAC II study on triple ACTs (TACTs) to treat multi-drug resistant falciparum malaria, DeTACT, a large project funded by DFID, will expand the evaluation of TACTs to African countries and aims to have 2 different TACTs ready for deployment by the end of the project.
The Malaria & Critical Illness Department’s future vision includes work in:
- Develop fixed dose triple ACTs (TACT) for treating multidrug resistant falciparum malaria
- Understanding the biology of artemisinin and partner drug resistant falciparum malaria
- Effects of drug resistance on gametocyte production and transmissibility
- Transcriptomic changes and biological correlates in multidrug resistant P. falciparum
- The spread and genetic epidemiology of multidrug resistant P. falciparum
- Testing new antimalarial compounds
- Role of malaria vaccines in malaria elimination in Southeast Asia
- Role of ivermectin in malaria elimination
- Forest worker malaria prophylaxis
- Improving housing in hot humid regions to reduce vector entry and prevent malaria
- Molecular epidemiology and phenotypes of PfHRP2/3 and PfLDH deleted P. falciparum in relation to their detection with rapid diagnostic tests
- Testing Highly Sensitive (HS)-RDTs to guide FSAT / MSAT approaches for malaria elimination
- Paracetamol as reno-protective therapy in African children with severe falciparum malaria
- The free haemoglobin-oxidative stress-AKI pathway in severe malaria
- The role of the gut microbioma in severe malaria
- Fluid management in severe falciparum malaria
- Optimising radical treatment of vivax malaria with primaquine: adapting current dosing recommendations to develop optimised weight and age-based dosing regimens of primaquine
- Developing innovative primaquine regimens for different regions to obviate the need to test for G6PD deficiency
- CYP2D6 genetic variants and their impact on primaquine efficacy
- Plasmodium vivax Controlled Human Infection Models (with HVCTU)
- Studies on the roll out of the radical cure for P. vivax at village and health post level.
- Understanding the contributors to intensive care performance in LMICs
- Developing sustainable training models to improve ICU care in LMICs
- Developing and implementing setting adapted ICU registries in LMICs
- The role of lung ultrasound in ICU in LMICs
- Probiotics to prevent ventilator associated pneumonia in LMICs
- Optimising mechanical ventilation strategies in LMICs
- Translating ICU guidelines developed in HIC to LMIC settings