Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
Chu CS., Phyo AP., Lwin KM., Win HH., San T., Aung AA., Raksapraidee R., Carrara VI., Bancone G., Watson J., Moore KA., Wiladphaingern J., Proux S., Sriprawat K., Winterberg M., Cheah PY., Chue AL., Tarning J., Imwong M., Nosten F., White NJ.
Vivax malaria relapses frequently even in low-transmission settings. Chloroquine delays but does not prevent recurrences. Adding primaquine to a slowly eliminated schizonticide significantly reduces recurrences and improves hematocrit, but this advantage is offset by hemolysis in G6PD-deficient females.