Pitfalls in Estimating Piperaquine Elimination
Tarning J., Lindegårdh N., Annerberg A., Singtoroj T., Day NPJ., Ashton M., White NJ.
ABSTRACT By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.