Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia.
Kobylinski KC., Satoto TBT., Nurcahyo W., Nugraheni YR., Testamenti VA., Winata IPBA., Pono YL., Timoria D., Assawasuwannakit P., Chambers M., Baird JK., Tarning J., von Seidlein L., Bøgh C.
The mosquito-lethal effect of commercially available standard and long-lasting ivermectin formulations were evaluated in cattle and buffalo against wild-caught Anopheles on Sumba Island, Indonesia. Cattle have substantially higher blood-level concentrations of ivermectin compared to buffalo after receiving similar doses, irrespective of formulation. In total, nine Anopheles species were captured to assess the mosquito-lethal effects of ivermectin with susceptibility ranked from lowest to highest: An. flavirostris