Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion
Imwong M., Suwannasin K., Srisutham S., Vongpromek R., Promnarate C., Saejeng A., Phyo AP., Proux S., Pongvongsa T., Chea N., Miotto O., Tripura R., Nguyen Hoang C., Dysoley L., Ho Dang Trung N., Peto TJ., Callery JJ., van der Pluijm RW., Amaratunga C., Mukaka M., von Seidlein L., Mayxay M., Thuy-Nhien NT., Newton PN., Day NPJ., Ashley EA., Nosten FH., Smithuis FM., Dhorda M., White NJ., Dondorp AM.
Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion.