Pharmacokinetic Study of Rectal Artesunate in Children with Severe Malaria in Africa
Fanello C., Hoglund RM., Lee SJ., Kayembe D., Ndjowo P., Kabedi C., Badjanga BB., Niamyim P., Tarning J., Woodrow C., Gomes M., Day NP., White NJ., Onyamboko MA.
When severe malaria is suspected in children, the WHO recommends pretreatment with a single rectal dose of artesunate before referral to an appropriate facility. This was an individually randomized, open-label, 2-arm, crossover clinical trial in 83 Congolese children with severe falciparum malaria to characterize the pharmacokinetics of rectal artesunate.