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Adding a third anti-malaria drug to current artemisinin-combination therapies (ACTs) provides effective treatment against multidrug-resistant falciparum malaria in Southeast Asia, say Oxford researchers in a study in The Lancet. Using TACTs should extend current malaria drugs so drug-resistant malaria doesn't kill millions more and derail hopes of controlling and eliminating malaria.
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MORU 2020. Photographer: Mehul Dhorda
Bioethics and Engagement
MORU runs an active community and stakeholder engagement programme, aiming to improve health and wellbeing in low-resource settings. We work with underserved groups to ensure our research is ethical, inclusive, and responsive to local needs. Using community advisory boards, participatory projects, an…
Research Areas
Patient-centred research is the core of our research activities, spanning 5 research units and over 50 research sites in Asia and Africa. Our integrated, highly collaborative, flexible structure of 5 research units and ~ 50 clinical research sites across Asia and Africa allows us to address global and regional health pr…
Celine Caillet: Detecting substandard and falsified medical products
The Medicine Quality Research Group focuses on substandard and falsified medicines, critical issues often overlooked in LMICs. Recent tragic incidents underscore the urgent need for better regulatory oversight. The group explores portable screening technologies to empower regulators in identifying and p…
Ben Cooper: Drug-resistant infections and disease dynamics
Infectious diseases carry a huge impact and developing interventions remains a priority. A recent trial in Southeast Asia aimed at shortening antibiotic treatment for ventilator-associated pneumonia, reducing side effects and the risk of antimicrobial resistance. Collaborations underline the global AMR burde…
Bipin Adhikari: Community engagement for malaria elimination
Community engagement is important for ethical research, understanding community vulnerabilities and aligning priorities to bridge the gap between researchers and the communities they serve. MORU researchers focus on social aspects of infectious diseases, primarily malaria, with recent projects in La…
Paul Turner: Improving data for infection management
The ACORN project gathers clinical, microbiology, and antibiotic use data from nine countries in Asia and Africa to understand the burden and impact of antibiotic resistance on patient treatment and outcomes. It aims to improve direct patient care, generate treatment guidelines, and inform interventions to…
Carlo Perrone: Improving scrub typhus detection and prevention
In northern Thailand, MORU researchers focus on scrub typhus, a disease transmitted by small bugs in rural environments. A simple diagnostic cartridge for rapid detection would avoid critical delays and issues of current antibody-based tests. If accessible in small hospitals, this improved diagnostics has the pote…
Claire Chewapreecha: Melioidosis genomics
Genetic investigations into melioidosis, profiling both bacteria and patients, help understand disease acquisition and outcomes. Furthermore, identifying prevalent harmful bacterial genes supports vaccine development, and the development of CRISPR-Cas-based tests responds to an urgent need for rapid dia…
Stuart Blacksell: Risk-based approach to biosafety
In biosafety and biosecurity, the recent risk-based approach departs from a rigid one-size-fits-all model. Tailoring safety measures to pathogen and activity levels enhances flexibility, which is vital in resource-limited settings. Systematic reporting of lab incidents globally is lacking, hindering transparency and roo…
Direk Limmathurotsakul: AMR: local, national, global impact
To fight antimicrobial resistance, researchers at MORU utilise hospital data to assess global impact and guide interventions. By analysing data, they identify hospitals needing support which enables targeted interventions. Automation and simplification aid data utilization in low-middle-income countries. This appr…
Nick White: Improving the treatment of infectious diseases
With nearly 50 years in malaria research and more recent focus on COVID-19, research at MORU led to more effective treatments. In COVID-19, trials debunked drugs like ivermectin or favipiravir, but validated remdesivir, molnupiravir and protease inhibitors. As malaria faces drug resistance, triple therapi…
Naomi Waithira: Data, science and health
MORU Data Management focuses on tropical infectious diseases, gathering data from diverse sources like patient interviews, medical records and laboratory results. This data, stripped of identifying information, is organized for analysis. Past clinical data aids new insights, augmented by mathematical modelling a…