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An unconventional clinical trial design might have advantages over classical trials for testing treatments for Ebola virus disease (EVD), suggests a study published this week in PLOS Medicine. The work of an international team led by John Whitehead of Lancaster University, UK and Ben Cooper (Oxford University, UK, and Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand) provides much-needed data to inform a debate on the scientific and ethical justification for non-randomized EVD trials that has taken place in the editorial pages of a number of medical journals in past months.
MORU Bangkok
Established in 1979 as a research collaboration between Thailand's Mahidol University and the UK's University of Oxford and Wellcome, the Mahidol Oxford Tropical Medicine Research Unit (MORU) and its Departments, laboratories and Operations & Admin are headquartered in Bangkok, Thailand within Mahidol's Faculty of Tropical Medicine.
MOCRU (Myanmar)
Led by Prof Frank Smithuis, formerly of Médécins sans Frontières (MSF) and later of Medical Action Myanmar (MAM), the Myanmar Oxford Clinical Research Unit (MOCRU) was established in 2013.
COMRU (Cambodia)
Embedded within the Angkor Hospital for Children (AHC) in Siem Reap, Cambodia, the Cambodia-Oxford Medical Research Unit (COMRU) was established in 2006 as a collaboration between MORU and AHC, a non-profit paediatric teaching hospital and clinical training site for Cambodian doctors, nurses, medical students and health workers that provides free, quality healthcare to children. COMRU’s research focuses on the causes and reduction of morbidity and mortality in Cambodian children.
LOMWRU (Lao PDR)
Located in Vientiane, the main objective of the Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU) is to conduct clinical research on diseases of public health importance, to contribute directly to health improvement in Laos and similar communities with little health information across Asia.
SMRU (Thailand)
Founded in 1986 to work in camps for refugees from Myanmar, the Shoklo Malaria Research Unit (SMRU) provides quality health care to the marginalized populations living on both sides of the Thai-Myanmar border in the Mae Sot area, Tak Province. It does this by combining research and humanitarian services, with an emphasis on mother and child health and infectious diseases. In 2018 the Borderland Health Foundation was registered in Thailand as a legal structure attached to SMRU to further develop the non-research activities.