In Vitro-Clinical Correlations for Amphotericin B Susceptibility in AIDS-Associated Cryptococcal Meningitis
Larsen RA., Bauer M., Brouwer AE., Sanchez A., Thomas AM., Rajanuwong A., Chierakul W., Peacock SJ., Day N., White NJ., Rinaldi MG., Harrison TS.
ABSTRACT Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.