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In a clinical isolate of Burkholderia pseudomallei from Hainan, the association between the emergence of ceftazidime resistance and a novel PenA P174L allele was identified for the first time, providing an understanding of one mechanism by which ceftazidime resistance arises in B. pseudomallei.

Original publication

DOI

10.1016/j.drup.2024.101121

Type

Journal

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Publication Date

09/2024

Volume

76

Addresses

NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine and The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan, China.

Keywords

Humans, Burkholderia pseudomallei, Melioidosis, Ceftazidime, Bacterial Proteins, Anti-Bacterial Agents, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Point Mutation, Alleles, China